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Post Doctoral Fellow

Posting Details

Posting Information

Position Title Post Doctoral Fellow
Position Status
Basic Function

A post-doctoral fellow position funded by the NSF is available immediately at Worcester Polytechnic Institute (WPI) in the Biomedical Engineering Department working with Professor Albrecht. This position will support research studying neural circuit dynamics in living, behaving organisms, particularly long-term changes associated with learning, sleep, and neurological disorders. This project will use our newly-developed methods for multi-neural imaging and chemical or optogenetic stimulation using “light-sheet” or selective plane illumination microscopy (SPIM).

We seek outstanding candidates with a neuroscience and/or microscopy background and an excitement for asking novel questions about brain function using cutting-edge technology. Examples include investigating (1) sources and mechanisms of behavioral variability, attention, and decision making; (2) neural response changes during learning, and sleep state transitions; and (3) dynamic activity patterns arising from targeted neural activation. The successful candidate will interface with project collaborators at WPI, U Mass Medical School, Yale and NIH, with further opportunities to network in Boston and at the Marine Biological Lab at Woods Hole.

For more information, please visit our website at

Recent publications are available on SPIM light-sheet microscopy:

• Wu, et al. “Spatially isotropic four-dimensional imaging with dual-view plane illumination microscopy” Nature Biotechnology 31, no. 11 (2013): 1032–1038. doi:10.1038/nbt.2713

and our methods for long-term single-neuron imaging in behaving animals:

• Larsch, et al. “High-throughput imaging of neuronal activity in C. elegans.” PNAS 110(45):E4266-E4273 (2013).
• Larsch, et al. “A circuit for gradient climbing in C. elegans chemotaxis.” Cell Reports 12(11):1748-60. doi: 10.1016/j.celrep.2015.08.032 (2015).

About our location: Founded in 1865, WPI is one of the nation’s oldest technological universities. Today, WPI is a highly selective private university with over 4,000 undergraduate and 1,900 graduate students enrolled in more than 50 Bachelor’s, Master’s and Ph.D. programs, and is consistently ranked among the top national universities in U.S. News & World Report. The university is located in the heart of Massachusetts, an hour away from Boston and Providence. The Biomedical Engineering and Biology & Biotechnology departments are housed in the Life Sciences and Bioengineering Center, along with biochemistry and biophysics labs, providing an exciting “critical mass” for interdisciplinary projects. WPI labs collaborate extensively with U Mass Medical School clinicians and biomedical departments such as Neurobiology

Posting Date 04/18/2017
Closing Date
Special Instructions to Applicants
EEO Information

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, color, age, religion, sex, sexual orientation, gender identity, national origin, veteran status or disability. We are looking for individuals who value creativity, diversity, inclusion, and collaboration.

Criminal Background check statement

A pre-employment criminal records check is required.

Principal Duties and Responsibilities

Principal Duty and Responsibility

This position will involve working with a team of graduate students and collaborators to develop and apply new stimulation methods for long term optical recording of multiple neurons in different model systems including nematodes. The post-doc associate will also be expected to participate in preparing research articles, presenting research findings at conference meetings, and contributing to grants. Therefore, excellent writing and communication skills are important.

Position Requirements


Applicants should have an earned Ph.D. degree in neuroscience, biology, biomedical engineering, biophysics or a closely related field. A strong research background in organism behavior, live cell imaging, and/or molecular biology/genetics is essential. Some experience with image analysis, computational techniques, MATLAB or other programming language, is preferred.

Supplemental Questions

Required fields are indicated with an asterisk (*).

Applicant Documents

Required Documents
  1. Cover Letter
  2. Curriculum Vitae
  3. List of References
Optional Documents